acceptodds
Under review as a conference paper at ICLR 2027

A Decodability-Grounded Audit of Clinical Prediction Claims in PPG Foundation Models

Abstract

What does held-out clinical prediction from photoplethysmography (PPG) reveal about physiology? We audit frozen representations through concept decodability, covariate-adjusted and incremental prediction, and post-erasure predictability after probe refitting, with encounter-matched ECG comparisons. Across four encoders and MC-MED encounters, AnyPPG decodes pulse-derived concepts well. For potassium on matched encounters, its correlation falls from to after age and renal adjustment, whereas ECGFounder retains (paired adjusted difference ; 95% CI ). Creatinine likewise attenuates under target-derivative-free adjustment. On a separate -encounter complete-case cohort, adding ECGFounder to the same age, estimated glomerular filtration rate (eGFR), and blood urea nitrogen (BUN) baseline raises potassium correlation by about under ridge and nonlinear predictors; direct AnyPPG increments have confidence intervals including zero. Erasure loss gives the opposite modality ordering from interval decodability: after rank-five subspace removal and refitting, AnyPPG loses in adjusted correlation versus ECGFounder's . AnyPPG starts from a much lower adjusted correlation; its loss is near the heart-rate control. Together, these results identify adjustment-sensitive PPG potassium prediction and stronger retained ECG association, while decodability and erasure capture complementary aspects of the representations.

Then back it, or bet against it.

Related papers

Open the market on this paper to see 7 more related papers.