${\mathrm{S}}^3$-PnP: Plug-and-Play Denoising for Scientific Imaging with Self-Supervised Score Priors

Modern image restoration methods increasingly rely on large-scale supervised training, yet clean targets are often prohibitively difficult to obtain in scientific imaging modalities such as hyperspectral imaging (HSI) and magnetic resonance imaging (MRI). Plug-and-play ADMM (PnP-ADMM) with pretrained diffusion priors offers a promising alternative, but the learned prior distribution can mismatch both the target scientific image distribution and the distribution of ADMM denoiser inputs induced by dual feedback. To mitigate these mismatches, we propose S³-PnP, a self-supervised plug-and-play restoration framework that learns a score prior directly from observation-derived ADMM intermediate states, without clean training targets or externally pretrained weights. Specifically, the learned score corrects the input to the analytical prior update, combining observation-driven corrections with analytical regularization. We further analyze the convergence and reconstruction error of the corrected ADMM algorithm assuming an ideal score and quadratic data fidelity. Experiments on reference-guided HSI restoration, single-image HSI denoising, and MRI denoising demonstrate consistent improvements over competing methods.